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. 2020 Apr 9;217(6):e20191257. doi: 10.1084/jem.20191257

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© 2020 Badhai et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 3. — Mouse and human mesothelioma cells hypersensitive to PI3K inhibition, PARP inhibition, and radiation. (A) Dose-response curve of BNC (n = 2) and NC (n = 2) mesothelioma cells to PI3K inhibitor BEZ-235. (B) Immunoblot showing p-AKT, total AKT, and Tubulin in BEZ-235–treated BNC (n = 2) and NC (n = 2) mesothelioma cells. (C and D) Dose-response curve of two independent BNC and NC mesothelioma cells to γ-radiation (C) and PARP inhibition (D). (E) Copy number alteration profile of genomic losses and gains as determined by CGHcall in both BNC (n = 10) and NC (n = 4) tumors.