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. 2020 Apr 9;217(6):e20191257. doi: 10.1084/jem.20191257

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© 2020 Badhai et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 4. — Mouse BNC mesothelioma shows improved survival upon cisplatin plus pemetrexed treatment. (A) Survival curve of vehicle- (n = 13) and cisplatin + pemetrexed (Cis+Pem)–treated (n = 15) BNC mouse. (B) Quantification of tumor burden in the thoracic cavity in treated and control cohorts. The y axis represents values in the scale of 1 to 10. 10 is the highest tumor burden in that cohort, and 0 is no tumor. Error bars represent mean ± SEM. (C) Cleaved Caspase-3, Ki-67, and p53 staining of treated and untreated BNC tumors. Scale bars are 20 µm. All mice used had mixed C57BL/6 and FVB background. Littermates were used in this experiment. Unpaired Student’s t test was used to analyze data in B. ***, P < 0.001.