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. 2020 May 8;217(6):e20200343. doi: 10.1084/jem.20200343

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© 2020 Van Kaer and Joyce

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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graphic file with name JEM_20200343_Fig2.jpg — iNKT cells coopt the evolutionarily conserved Hippo signaling pathway to control their maturation and terminal differentiation. (A) Salient features of thymic iNKT cell maturation and effector subset differentiation. (B) Core components of the mammalian canonical Hippo signaling pathway, and common cellular inputs and outcomes. (C) Model for the consequences of Mst signaling on the maturation and terminal effector differentiation of iNKT1 cells and its association with IL-15R signaling, based on the new work from Raynor et al. (2020).