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. 2021 Mar 13;10(1):424–438. doi: 10.1080/22221751.2021.1895679

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — HAdV-55 challenge on pre-vaccinated tree shrews. (a) Experimental scheme of tree shrew challenge studies. Eleven tree shrews (immunized group) were intramuscularly vaccinated with inactivated HAdV-55 virions and 8 (control group) were intramuscularly vaccinated with MEM. Sera from the tree shrews were collected for NAb detection. The tree shrews were challenged with HAdV-55, and then humanely euthanized on days 3 and 5 post-challenge to collect their blood and tissues. Body weight, body temperature, and behaviour were measured daily. Viral loads in tissues and daily swabs were monitored. (b) The neutralizing antibody titres against HAdV-55 in sera from vaccinated tree shrews were detected by a micro-neutralization test. (c) Body weight and (d) body temperature was monitored at the indicated time points. (e) Viral DNA load in oropharyngeal swabs. (f) Viral DNA load in turbinate bone. (g) Viral DNA load in lung tissues. Each symbol represents an individual tree shrew, and the horizontal lines indicate the mean values or the mean ± standard deviation (SD). Statistically significant differences between the immunized and control groups are denoted by * (P < 0.05), ** (P < 0.01).