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. 2021 Mar 14;59(1):301–308. doi: 10.1080/13880209.2021.1889002

Figure 4.

Figure 4.

Phy suppressed MCF-7-xenograft tumour growth in BALB/c mice. The BALB/c mouse model was treated with Phy at 30 mg/kg every other day for 28 days. (A) Tumour-bearing nude mice. (B) Tumour tissue specimens. (C) Tumour sizes of MCF-7-xenografted mice in the control and Phy-treated groups. Tumour sizes are expressed as mean ± S.D. (n = 3). ***p < 0.001 versus control group. (D) Mean (± S.D.) body weight of the control and Phy-treated mice (n = 3). (E) Phy enhanced the phosphorylation of IκBα and NF-κB, and reduced the expression levels of Nrf2 and its downstream proteins. Quantitative protein expression data were normalized to the corresponding GAPDH levels, and the average fold changes in band intensity are marked (n = 3). Haematoxylin and eosin staining of liver (F) and spleen (G) tissues from nude mice.