. Author manuscript; available in PMC: 2021 Mar 18.

Published in final edited form as: Cancer. 2019 Dec 6;126(5):994–1003. doi: 10.1002/cncr.32591

Table 2.

Survival outcomes in Group A patients according to leukocyte counts using the new specific OSCC^a cutoffs

	Number of patients (n=1369)	5-year OS^b %	HR^c (95% CI^d)	P value	5-year DSS^e %	HR (95% CI)	P value

Neutrophils¹
≤ 4.8	770	69.7	1	< 0.001	83.2	1	< 0.001
4.8–9.1	549	59.4	1.536 (1.295–1.822)		76.4	1.539 (1.185–1.999)
≥ 9.1	50	31.5	3.076 (2.170–4.360)		59.9	3.069 (1.816–5.186)

Monocytes¹
≤ 0.3	577	71.3	1	< 0.001	83.3	1	0.014
> 0.3	792	58.6	1.473 (1.240–1.749)		76.9	1.387 (1.068–1.802)

Lymphocytes¹
≤ 0.8	69	41.4	1	< 0.001	75.6	1	0.246
> 0.8	1300	65.3	0.427 (0.314–0.579)		80.0	0.709 (0.396–1.267)

NLR^f
≤ 2.9	783	69.5	1	< 0.001	83.1	1	< 0.001
2.9–5.7	481	61.9	1.376 (1.151–1.646)		77.8	1.462 (1.114–1.919)
≥ 5.7	105	35.6	3.083 (2.396–3.967)		61.6	2.941 (1.976–4.377)

SIRI^g
≤ 1.0	675	72.5	1	< 0.001	84.0	1	< 0.001
1.0–1.9	450	62.2	1.543 (1.273–1.871)		79.0	1.404 (1.046–1.885)
≥ 1.9	244	44.5	2.485 (2.017–3.061)		67.9	2.261 (1.644–3.111)

^a-

OSCC: oral cavity squamous cell carcinoma;

^b-

OS: overall survival;

^c-

HR: hazard ratio;

^d-

CI: confidence interval;

^e-

DSS: disease-specific survival;

^f-

NLR: neutrophil-to-lymphocyte ratio;

^g-

SIRI: Systemic Inflammation Response Index.

^1:

Units × 10⁹/L