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. Author manuscript; available in PMC: 2021 Mar 18.
Published in final edited form as: J Neurol Neuromedicine. 2018;3(5):13–18. doi: 10.29245/2572.942x/2018/5.1220

Table 3.

Selected Summary of Observational Epidemiology of Body Mass Index, Cognition and Late-Onset, Sporadic Dementias.

Cross-sectional analyses

  • Late-life low BMI → prevalent LOD28

  • Late-life higher adiponectin → worse cognition and worse AD brain neuroimaging outcomes29

  • Mid-life higher adiposity → better cognition among a vulnerable sample30

Longitudinal analyses

  • First Report: Late-life more overweight among women born 1901/02 in their 70s →AD at ≥ 80 years31

  • Higher waist-to-hip ratio → higher LOD risk after 32 years32

  • Declining BMI preceding LOD and with usual aging8

  • 37 year natural history of BMI and LOD33

  • Steeper late-life BMI decline with APOEε4 allele among those with and without LOD8

  • Late-life low BMI → LOD within 5 years34

  • Higher BMI + no APOEε4 → slower AD progression over 1y based on CDR-Sum of boxes35

  • Lower BMI + APOEε4 → faster AD progression over 1y based on CDR-Sum of boxes35