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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Adv Nanobiomed Res. 2020 Nov 26;1(1):2000040. doi: 10.1002/anbr.202000040

Figure 8. Nanocomposite-mediated neurotoxicity mitigation and Aβ removal in an AD mouse model.

Figure 8.

(A) The Aβ-nanocomposite interaction entailed mitigation of Aβ aggregation and associated neurotoxicity. (B) Fluorescence images showing the Aβ/NC-KLVFF clusters elimination by BV-2 cells pretreated with or without TNF-α. Aβ was labeled with FITC (green), while NC-KLVFF was labeled with rhodamine B (red). Scale bar: 25 μm. (C) The nanocomposite mitigated the neurotoxicity elicited by Aβ aggregation in an AD mouse model. In situ neuronal apoptosis in hippocampal dentate gyrus subregion was labeled red. Reproduced with permission from Ref. 22. Copyrights 2019 American Chemical Society.