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. 2021 Mar 18;16(3):e0248689. doi: 10.1371/journal.pone.0248689

Fig 5. Changes in the mitogen-activated protein kinase (MAPK) cascade in the hippocampus.

Fig 5

Left. Ratio of phosphorylated extracellular signal-regulated kinases (p-ERK) to ERK. Middle. Ratio of phosphorylated c-Jun NH2-terminal kinases (p-JNK) to JNK. Right. Ratio of phosphorylated p38 kinase (p-p38) to p38 in the hippocampus. Sham, sham-operation group; CI, cerebral ischemia-induced group; CI-PDRN, cerebral ischemia-induced and polydeoxyribonucleotide (PDRN)-treated group; CI-PDRN+DMPX, cerebral ischemia-induced and PDRN with 7-dimethyl-1-propargylxanthine (DMPX)-treated group. * indicates P < 0.05 compared with the sham-operation group. # indicates P < 0.05 compared with the cerebral ischemia-induced group.