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. 2021 Mar 18;16(3):e0248689. doi: 10.1371/journal.pone.0248689

Fig 7. Changes in phosphorylated cAMP response element-binding protein (p-CREB) to CREB ratio and phosphorylated protein kinases A (p-PKA) to PKA ratio.

Fig 7

Left. Ratio of p-CREB to CREB in the hippocampus. Right. Ratio of p-PKA to PKA in the hippocampus. Sham, Sham-operation group; CI, cerebral ischemia-induced group; CI-PDRN, cerebral ischemia-induced and polydeoxyribonucleotide (PDRN)-treated group; CI-PDRN+DMPX, cerebral ischemia-induced and PDRN with 7-dimethyl-1-propargylxanthine (DMPX)-treated group. * indicates P < 0.05 compared with the sham-operation group. # indicates P < 0.05 compared with the cerebral ischemia-induced groups.