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. 2021 Mar 18;16(3):e0246613. doi: 10.1371/journal.pone.0246613

Fig 8. Immunization with Anhui/13 A169T H7 VLP.

Fig 8

C57BL/6 mice (8 mice) was vaccinated with Anhui/169T H7 VLPs at week 0 and 4. Vaccinated mice were bled and the serum was tested for the antigenic breath across panel H7 strains (A). At week 8, vaccinated mice were intranasally infected with 10e+5 PFU of the A/Anhui/1/2013 H7N9) virus. Mice were monitored daily for weight loss and survival (C and D, respectively) and viral lung titers in selected mice at day 4 post infection (B). Weight loss and lung viral titer was presented as mean± standard deviation (A&C). *p<0.05, ****p<0.0001.