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. 2021 Mar 18;17(3):e1009358. doi: 10.1371/journal.ppat.1009358

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© 2021 Briard et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — ZBP1 senses C. albicans and A. fumigatus infection to mediate PANoptosome (ZBP1-RIPK1-RIPK3-FADD-CASP8) complex formation and drive PANoptosis, inflammatory cell death characterized by NLRP3/CASP1 activation (pyroptosis), CASP3/CASP7 activation (apoptosis), and MLKL activation (necroptosis). ASC, apoptosis-associated speck-like protein containing a caspase activation and recruitment domain; CARD, caspase activation and recruitment domain; CASP, caspase; DD, death domain; DED, death effector domain; FADD, fas-associated death domain protein; GSDMD, gasdermin D; LRR, leucine-rich repeat; MLKL, mixed lineage kinase domain-like pseudokinase; NLRP3, nucleotide-binding domain and leucine-rich repeat family pyrin domain-containing 3; PYD, pyrin domain; RHIM, receptor-interacting protein homotypic interaction motif; RIPK, receptor-interacting serine/threonine kinase; ZBP1, Z-DNA-binding protein 1.