Table 2. Comparison of parameters between the extubation success and failure group in the derivation cohort.
| Success (101) | Failure (09) | p | |
|---|---|---|---|
| Respiratory Comorbidity * | 45 (45) | 5 (55) | 0.729 |
| Cardiac Comorbidity * | 24 (24) | 1 (11) | 0.681 |
| Neurologic Comorbidity * | 28 (27.7) | 6 (67) | 0.024 |
| Two or more comorbidities * | 22 (22) | 4 (44) | 0.211 |
| SOFA score ** | 5 (4–6) | 5 (4–8) | 0.356 |
| Days of Mechanical Ventilation** | 5 (2–7) | 5 (4–10) | 0.064 |
| Days of Sedation** | 3 (2–10) | 3 (1–4) | 0.522 |
| Estimated Glasgow Coma Scale** | 14.7 (13.3–14.7) | 14.3 (8.8–14.7) | 0.136 |
| Muscle Strength (MRC) ** | 48 (48–54) | 48 (24–48) | 0.081 |
| Fluid Balance—last 24h (ml) ** | 510 (-365–1625) | 576 (-154–1176) | 0.831 |
| Fluid Balance—ICU stay (ml) ** | 3876 (1088–8411) | 4435 (281–7530) | 0.802 |
| Creatinine (mg/dL) ** | 0.86 (0.68–1.71) | 1.23 (0.7–2.45) | 0.386 |
| Urea (mg/dL) ** | 52 (34.6–81.4) | 54.2 (43.9–98) | 0.549 |
| Hematocrit (%) *** | 29.1 ± 5.7 | 25.7 ± 7.4 | 0.100 |
| Dynamic Lung Compliance (ml/cmH2O) ** | 56.2 (43.7–66.1) | 44.2 (43.7–48.8) | 0.047 |
| Arterial pH** | 7.47 (7.39–7.53) | 7.49 (7.44–7.53) | 0.520 |
| Arterial PO2 (mmHg) ** | 85.2 (66.6–125.5) | 103.1 (85.5–125.5) | 0.346 |
| Arterial PCO2 (mmHg) ** | 31.3 (26.4–34) | 30.2 (27.7–33.6) | 0.896 |
| HR in MV ** | 85 (71.5–95.5) | 87 (74.5–98.5) | 0.739 |
| HR in SBT ** | 85 (69.2–97) | 80 (69–94) | 0.628 |
| SatO2 (%) in MV ** | 97 (96–98) | 98 (97–99) | 0.398 |
| SatO2 (%) in SBT ** | 97 (95–98) | 98 (96–99) | 0.163 |
| RR in MV ** | 20 (16–23.5) | 23 (19–23.5) | 0.125 |
| RR in SBT ** | 21 (17–23.7) | 22 (18.5–27.5) | 0.310 |
| Tidal Volume (ml/Kg) in MV ** | 8.1 (7–10.1) | 6.4 (5.9–7.6) | 0.016 |
| Tidal Volume (ml/Kg) in SBT ** | 7.2 (6–8.4) | 6.4 (4.2–7.6) | 0.098 |
| RSBI in MV (breaths/min/L) ** | 38 (29.5–50.9) | 57.5 (48–66.3) | 0.003 |
| RSBI in SBT (breaths/min/L) ** | 47.5 (36.6–58.2) | 62.8 (51.5–87) | 0.006 |
*presented as absolute and relative frequency and applied Fisher Exact test.
**presented as median and interquartile range and applied Mann-Whitney U test.
***presented as mean ± standard deviation and applied Student t test.
SOFA: Sequential Organ Failure Assessment. MRC: Medical Research Council. ICU: Intensive Care Unit. HR: Heart Rate. MV: Mechanical Ventilation. SBT: Spontaneous Breathing Trial. RR: Respiratory Rate.