TABLE 2a.
Longitudinal factor levels in patients receiving no blood products within 72h of arrival
| 0h | 6h | 12h | 24h | 48h | 72h | |
|---|---|---|---|---|---|---|
| PT (sec) | 13.8 (13.1 – 15.4)* | 14.7 (13.8 – 15.6)# | 14.4 (13.7 – 15.7)# | 15.6 (14.2 – 16.8)# | 15.2 (14.0 – 16.2)# | 14.6 (14.2 – 16.5)# |
| PTT (sec) | 29.8 (26.7 – 33.8)* | 30.9 (28.8 – 34.9)# | 33.1 (29.3 – 36.5)# | 38.6 (33.7 – 42.8)# | 42.0 (37.1 – 49.5)# | 44.6 (39.9 – 46.9)# |
| Fibrinogen (ng/mL) | 234 (151 – 289) | 260 (233 – 306) | 251 (211 – 303) | 233 (208 – 259) | 506 (350 – 582) | 720 (622 – 818) |
| Factor II (%) | 81.4 ± 19.1* | 74.7 ± 18.2# | 75.9 ± 18.0# | 73.1 ± 17.6# | 69.5 ± 19.1# | 83.2 ± 18.7 |
| Factor V (%) | 56.5 ± 27.9* | 56.7 ± 24.0# | 56.6 ± 21.2# | 57.2 ± 22.1# | 68.0 ± 22.3# | 81.3 ± 29.3# |
| Factor VII (%) | 95.4 ± 33.9* | 95.9 ± 28.9 | 94.0 ± 30.6 | 67.6 ± 26.9# | 61.3 ± 33.0# | 81.1 ± 29.4 |
| Factor VIII (%) | 218.8 ± 171.8 | 136.6 ± 106.5# | 128.5 ± 76.3# | 137.6 ± 127.7# | 139.4 ± 53.2# | 177.0 ± 63.4# |
| Factor IX (%) | 129.2 ± 40.9* | 130.1 ± 45.9 | 138.1 ± 46.8# | 140.8 ± 43.5# | 172.2 ± 58.4# | 226.2 ± 93.1# |
| Factor X (%) | 86.3 ± 22.9* | 78.7 ± 23.1# | 79.8 ± 22.0# | 74.5 ± 18.6# | 66.3 ± 17.1# | 76.2 ± 20.6 |
| AT III (%) | 89.8 ± 21.8* | 87.3 ± 31.4 | 84.8 ± 22.2# | 83.7 ± 21.0# | 83.1 ± 23.4 | 84.1 ± 28.3 |
| Protein C (%) | 96.4 ± 28.8* | 92.1 ± 23.3# | 89.5 ± 27.0# | 81.5 ± 24.7# | 81.9 ± 23.0 | 87.0 ± 25.0 |
| aPC (ng/mL) | 3.1 (1.5 – 9.5)* | 0.9 (0.2 – 2.1)# | 1.0 (0.2 – 1.7)# | 1.2 (0.2 – 1.7)# | 1.0 (0.1 – 1.8)# | 0.6 (0.3 – 1.4)# |
| D-dimer (mcg/mL) | 1.7 (0.5 – 4.0)* | 1.6 (0.7 – 3.6)# | 2.3 (0.9 – 4.1)# | 2.4 (1.0 – 4.0) | 1.7 (1.0 – 4.2) | 1.9 (1.3 – 3.1) |
| tPA (ng/mL) | 15.2 (8.4 – 27.3)* | 12.1 (6.9 – 19.0)# | 6.0 (4.6 – 14.2)# | 6.7 (5.7 – 9.4)# | 6 | 6.7 |
| PAI-1 (ng/mL) | 38.0 (9.6 – 60.7) | 73.4 (44.1 – 91.4) | 38.8 (19.3 – 55.2) | 33.2 (17.8 – 71.0) | 11.7 (8.1 – 15.0) | 17.4 |
PT = prothrombin time; PTT = activated partial thromboplastin time; AT III = antithrombin III; aPC = activated Protein C; tPA = tissue plasminogen activator; PAI-1 = plasminogen activator inhibitor-1. N=193.
*
p <0.05 for comparison between transfused and non-transfused patients on arrival only.
#
p <0.05 for comparison between admission factor level and factor level at the indicated time.