TABLE 2b.
Longitudinal factor levels in patients receiving blood products within 72h
| 0h | 6h | 12h | 24h | 48h | 72h | |
|---|---|---|---|---|---|---|
| PT (sec) | 15.7 (14.2 – 19.6)* | 15.6 (14.4 – 17.8) | 15.7 (14.7 – 17.1) | 16.7 (15.5 – 18.2) | 16.6 (14.9 – 18.8) | 15.5 (14.3 – 17.3) |
| PTT (sec) | 30.8 (26.9 – 38.3)* | 32.8 (28.9 – 38.0)# | 34.3 (31.8 – 39.6)# | 38.6 (34.5 – 43.6)# | 40.8 (36.6 – 47.4)# | 39.0 (33.8 – 43.8)# |
| Fibrinogen (ng/mL) | 160 (125 – 221) | 153 (124 – 226) | 196 (152 – 237) | 288 (189 – 340)# | 398 (281 – 566)# | 499 (294 – 716)# |
| Factor II (%) | 66.5 ± 21.2* | 62.2 ± 16.6# | 63.8 ± 16.0# | 64.0 ± 16.0# | 65.6 ± 17.5 | 70.0 ± 15.4 |
| Factor V (%) | 41.5 ± 26.1* | 41.4 ± 19.6# | 43.3 ± 18.7 | 46.5 ± 21.0 | 54.6 ± 27.5# | 74.2 ± 39.2# |
| Factor VII (%) | 75.1 ± 34.9* | 99.3 ± 61.8# | 94.5 ± 60.2# | 52.7 ± 28.8# | 58.6 ± 29.4# | 76.2 ± 30.3 |
| Factor VIII (%) | 219.6 ± 144.8 | 128.6 ± 94.5# | 115.6 ± 73.7# | 119.1 ± 71.8# | 150.7 ± 124.2# | 179.5 ± 88.9# |
| Factor IX (%) | 103.6 ± 40.2* | 114.9 ± 38.8# | 115.6 ± 33.0# | 119.6 ± 35.0# | 155.7 ± 46.0# | 185.2 ± 50.4# |
| Factor X (%) | 66.7 ± 24.4* | 68.3 ± 26.3 | 66.2 ± 21.3# | 61.4 ± 15.7# | 64.1 ± 15.6# | 70.7 ± 17.6# |
| AT III (%) | 78.1 ± 24.6* | 72.1 ± 19.4# | 76.3 ± 17.9 | 73.9 ± 18.3# | 67.3 ± 19.6# | 74.3 ± 23.0 |
| Protein C (%) | 80.6 ± 28.0* | 69.9 ± 20.6# | 71.7 ± 18.7# | 66.8 ± 19.6# | 67.0 ± 22.6# | 73.7 ± 28.0 |
| aPC (ng/mL) | 12.1 (3.5 – 37.8)* | 1.9 (0.7 – 3.5)# | 1.2 (0.5 – 2.4)# | 1.0 (0.2 – 1.7)# | 1.3 (0.5 – 2.3)# | 1.2 (0.6 – 2.4)# |
| D-dimer (mcg/mL) | 6.8 (2.9 – 9.8)* | 6.5 (3.3 – 9.4) | 6.6 (3.8 – 9.9) | 5.2 (2.9 – 9.4)# | 3.3 (1.9 – 6.1)# | 3.6 (2.7 – 5.6)# |
| tPA (ng/mL) | 27.9 (13.0 – 44.0)* | 11.6 (9.9 – 18.9)# | 11.8 (8.7 – 15.1)# | 9.0 (5.9 – 12.9)# | 4.6 (4.3 – 5.3) | 4.5 (3.5 – 5.4) |
| PAI-1 (ng/mL) | 25.3 (12.1 – 33.4) | 130.2 (79.8 – 149.8)# | 135.1 (84.8 – 237.4)# | 70.4 (46.8 – 120.4)# | 26.0 (14.0 – 33.2) | 19.2 (13.8 – 24.6) |
PT = prothrombin time; PTT = activated partial thromboplastin time; AT III = antithrombin III; aPC = activated Protein C; tPA = tissue plasminogen activator; PAI-1 = plasminogen activator inhibitor-1. N=143.
*
p <0.05 for comparison between transfused and non-transfused patients on arrival only.
#
p <0.05 for comparison between admission factor level and factor level at the indicated time.