TABLE 3a.
Longitudinal factor levels in patients transfused with ‘low ratio’ (RBC:FFP <=1.5:1) at 6h
| 0h | 6h | 12h | 24h | 48h | 72h | |
|---|---|---|---|---|---|---|
| PT (sec) | 16.7 (14.5 – 21.2) | 15.3 (14.2 – 17.6) | 15.6 (14.6 – 16.9)# | 16.9 (15.5 – 19.1) | 16.2 (14.9 – 18.8) | 15.5 (14.1 – 17.8)# |
| PTT (sec) | 32.5 (27.5 – 42.2) | 33.2 (28.6 – 36.1)* | 33.7 (30.8 – 38.7)* | 38.2 (34.8 – 43.1)# | 39.2 (36.4 – 47.4) | 38.5 (32.9 – 43.8) |
| Fibrinogen (ng/mL) | 157 (106 – 200) | 142 (111 – 205) | 180 (133 – 234) | 288 (162 – 362)# | 325 (264 – 514)# | 494 (395 – 559)# |
| Factor II (%) | 66.2 ± 21.3* | 61.6 ± 17.1 | 64.4 ± 17.5 | 64.0 ± 18.5 | 66.8 ± 20.2 | 72.2 ± 14.4# |
| Factor V (%) | 38.7 ± 24.7 | 43.2 ± 20.7* | 43.7 ± 19.3 | 45.3 ± 23.4 | 58.8 ± 29.0# | 79.6 ± 44.2# |
| Factor VII (%) | 72.3 ± 31.7 | 107.0 ± 77.6# | 100.3 ± 69.7# | 48.2 ± 22.9# | 61.8 ± 34.6 | 79.6 ± 29.8 |
| Factor VIII (%) | 188.1 ± 128.5* | 115.3 ± 80.3# | 105.2 ± 62.2# | 110.6 ± 51.0# | 179.3 ± 147.7 | 192.9 ± 94.6 |
| Factor IX (%) | 101.2 ± 40.6 | 116.3 ± 39.4*# | 114.0 ± 35.4*# | 114.6 ± 36.7# | 151.6 ± 45.6# | 184.4 ± 46.2# |
| Factor X (%) | 64.1 ± 23.9 | 72.6 ± 33.4* | 65.0 ± 19.9 | 60.7 ± 17.9 | 66.2 ± 16.8 | 72.6 ± 15.7 |
| AT III (%) | 75.5 ± 24.9 | 67.6 ± 18.9 | 73.8 ± 17.6 | 69.8 ± 16.7 | 66.8 ± 21.0 | 72.4 ± 22.6 |
| Protein C (%) | 77.4 ± 29.0 | 66.8 ± 17.0 | 72.0 ± 18.5 | 64.5 ± 22.4# | 65.9 ± 21.6# | 73.4 ± 30.4 |
| aPC (ng/mL) | 15.3 (5.4 – 49.5) | 2.8 (0.7 – 4.7)# | 1.2 (0.6 – 2.5)# | 1.0 (0.5 – 1.9)# | 0.5 (0.3 – 1.7)# | 0.8 (0.6 – 2.4)# |
| D-dimer (mcg/mL) | 6.7 (2.4 – 9.8) | 6.4 (3.2 – 9.4) | 6.8 (3.8 – 10.6) | 7.6 (3.9 – 11.4) | 3.3 (2.1 – 5.0) | 3.7 (3.1 – 6.1) |
| tPA (ng/mL) | 31.0 (9.0 – 46.7) | 15.3 (11.2 – 22.6) | 13.5 (11.4 – 18.0)# | 9.8 (6.1 – 15.3)# | 4.3 | - |
| PAI-1 (ng/mL) | 25.3 (11.8 – 30.2) | 146.9 (138.7 – 372.4)# | 142.4 (134.2 – 278.9)# | 86.1 (57.7 – 124.6)# | 25.5 (8.3 – 33.5) | - |
PT = prothrombin time; PTT = activated partial thromboplastin time; AT III = antithrombin III; aPC = activated Protein C; tPA = tissue plasminogen activator; PAI-1 = plasminogen activator inhibitor-1. N=91.
*
p <0.05 for comparison between ‘low’ and ‘high ratio’ patients at each time point.
#
p <0.05 for comparison between admission factor level and factor level at the indicated time.