Table 3b.
Longitudinal factor levels in patients with 6h RBC:FFP ‘high ratio’ at 6h
| 0h | 6h | 12h | 24h | 48h | 72h | |
|---|---|---|---|---|---|---|
| PT (sec) | 16.2 (14.6 – 20.6) | 16.2 (15.1 – 18.3) | 15.9 (15.0 – 17.0) | 17.0 (15.8 – 17.7) | 17.6 (15.6 – 18.8) | 15.6 (15.2 – 17.3) |
| PTT (sec) | 32.5 (27.6 – 41.8) | 36.6 (32.5 – 41.7)*# | 35.9 (32.8 – 40.4)*# | 39.8 (36.0 – 46.4)# | 47.0 (38.6 – 49.5)# | 41.5 (39.4 – 45.8) |
| Fibrinogen (ng/mL) | 139 (125 – 205) | 124 (101 – 153) | 183 (157 – 230) | 258 (213 – 291)# | 547 (530 – 566)# | 668 (566 – 780)# |
| Factor II (%) | 57.7 ± 18.3* | 54.1 ± 14.9 | 59.4 ± 12.1 | 60.6 ± 12.4 | 61.8 ± 14.2 | 70.2 ± 15.4 |
| Factor V (%) | 38.0 ± 26.8 | 33.3 ± 16.2*# | 39.7 ± 16.7# | 43.2 ± 17.6 | 47.7 ± 25.3 | 61.0 ± 23.0 |
| Factor VII (%) | 73.9 ± 46.3 | 86.3 ± 51.8 | 101.1 ± 59.4 | 61.1 ± 36.3# | 52.9 ± 19.3# | 78.7 ± 32.7 |
| Factor VIII (%) | 266.6 ± 172.0* | 106.4 ± 77.4# | 106.2 ± 78.5# | 112.5 ± 43.7# | 114.1 ± 53.4# | 152.6 ± 78.1# |
| Factor IX (%) | 96.5 ± 44.2 | 86.5 ± 29.7* | 100.7 ± 18.5* | 107.1 ± 25.1 | 142.9 ± 36.1# | 179.0 ± 53.1# |
| Factor X (%) | 61.0 ± 23.1 | 54.7 ± 16.9* | 62.3 ± 20.9 | 58.2 ± 10.4# | 57.9 ± 12.9# | 72.7 ± 13.0 |
| AT III (%) | 73.8 ± 23.4 | 67.2 ± 19.7# | 74.7 ± 16.7# | 71.9 ± 20.0# | 61.2 ± 18.9# | 66.8 ± 24.1# |
| Protein C (%) | 79.5 ± 27.1 | 63.9 ± 17.8# | 69.7 ± 12.9# | 64.4 ± 15.1# | 57.7 ± 11.9# | 61.3 ± 18.6# |
| aPC (ng/mL) | 13.7 (3.5 – 51.2) | 1.4 (0.6 – 2.7)# | 1.0 (0.4 – 2.3)# | 0.5 (0.0 – 1.4)# | 1.2 (1.1 – 1.4)# | 1.2 (0.5 – 13.4) |
| D-dimer (mcg/mL) | 7.5 (3.8 – 12.0) | 6.5 (2.6 – 23.0) | 7.4 (4.2 – 14.6) | 7.4 (3.8 – 10.6)# | 4.7 (2.8 – 6.7) | 4.4 (3.2 – 6.7) |
| tPA (ng/mL) | 25.0 (14.7 – 38.3) | 12.5 (8.0 – 15.6)# | 10.2 (8.4 – 14.3)# | 6.8 (5.8 – 11.1)# | 5.0 (4.6 – 5.3) | 4.5 (3.5 – 5.4) |
| PAI-1 (ng/mL) | 25.7 (12.4 – 38.4) | 125.1 (49.5 – 132.6)# | 141.6 (84.1 – 251.4)# | 64.6 (43.8 – 143.4)# | 27.1 (19.1 – 33.2) | 19.2 (13.8 – 24.6) |
PT = prothrombin time; PTT = activated partial thromboplastin time; AT III = antithrombin III; aPC = activated Protein C; tPA = tissue plasminogen activator; PAI-1 = plasminogen activator inhibitor-1. N=52.
*
p <0.05 for comparison between ‘low’ and ‘high ratio’ patients at each time point.
#
p <0.05 for comparison between admission factor level and factor level at the indicated time.