Fig. 2. pVNT50 ratio of SARS-CoV-2 lineage B.1.1.7 to Wuhan reference strain spike–pseudotyped VSV.
Triangles represent sera from younger adults (aged 23 to 55 years), and circles represent sera from older adults (aged 57 to 73 years). Sera were drawn on either day 29 or day 43 (7 or 21 days after vaccine dose two). Geometric means of the pVNT50 ratios of SARS-CoV-2 lineage B.1.1.7 to Wuhan spike–pseudotyped VSV and 95% CIs are indicated. The difference in distribution of titer ratios between younger and older adults was tested for statistical significance with a two-tailed Mann-Whitney U test.