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. 2021 Mar 8;17(3):e1009263. doi: 10.1371/journal.pgen.1009263

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© 2021 Wang et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — (A) A scatter plot showing the significant APA changes induced by ICP27 over-expression in HEK293 cells. Color scheme and labeling are similar to Fig 1A. (B) A scatter plot showing the significant APA changes induced by U1 antisense morpholino oligo (AMO)-treatment of HEK293 cells. (C) A heat map of APA index of all genes that displayed significant APA changes induced by HSV-1-infection, ICP27 over-expression, or U1 AMO. Data was scaled by row. (D) PAS-seq tracks for two example genes. (E) GC content at the proximal and distal PAS of genes that displayed significant DtoP shifts induced by ICP27 over-expression (O/E), HSV-1 infection (HSV1), or U1 AMO treatment. (F) ICP27 CLIP signals at the proximal and distal PAS of genes that displayed significant DtoP shifts induced by ICP27 over-expression (O/E), HSV-1 infection (HSV1), or U1 AMO treatment.