Table 1.
Patient characteristics at baseline
| Preload responders (n = 15) | Preload non-responders (n = 15) | p value | |
|---|---|---|---|
| Age (years) | 63 ± 18 | 70 ± 10 | 0.37 |
| Male gender (n, %) | 12 (80.0) | 11 (73.3) | 0.32 |
| SAPS2 | 52 ± 15 | 56 ± 14 | 0.29 |
| Mortality (n, %) | 7 (46.7) | 6 (40.0) | 1.00 |
| Septic shock (n, %) | 11 (73.3) | 12 (80.0) | 0.14 |
| Cardiogenic shock (n, %) | 2 (13.3) | 2 (13.3) | 0.55 |
| Hypovolemic shock (n, %) | 1 (7.2) | 1 (7.2) | 1.00 |
| Vasoplegic shock (non-septic) (n, %) | 1 (7.2) | 0 (0.0) | 0.12 |
| CRRT (n, %) | 3 (20.0) | 4 (26.7) | 0.18 |
| ARDS (n, %) | 6 (40.0) | 5 (33.3) | 0.47 |
| Lactate (mmol/L) | 1.8 ± 0.6 | 1.3 ± 0.6 | 0.88 |
| PaO2/FiO2 | 228 ± 105 | 276 ± 105 | 0.55 |
| PEEP (cmH2O) | 10.7 ± 3.6 | 10.4 ± 3.0 | 0.63 |
| Crs (mL/cmH2O) | 31 ± 12 | 32 ± 13 | 0.66 |
| Acute cor pulmonale (n, %) | 0 (0.0) | 0 (0.0) | 1.00 |
| LVEF (%) | 45 ± 9 | 49 ± 11 | 0.67 |
| Patients receiving norepinephrine (n, %) | 15 (100.0) | 15 (100.0) | 1.00 |
| Dose of norepinephrine (µg/kg/min) | 1.2 ± 0.6 | 0.6 ± 0.4 | 0.02 |
P values in bold: < 0.05
ARDS acute respiratory distress syndrome, CRRT continuous renal replacement therapy, Crs compliance of the respiratory system, LVEF left ventricular ejection fraction, PaO2/FiO2 ratio of the arterial oxygen partial pressure over the oxygen inspired fraction, PEEP positive end-expiratory pressure, SAPS simplified acute physiologic score