Table 4.
Ability of different variables to detect preload responsiveness
| r versus PLR-induced changes in CI | p versus 0.5 | AUROC | sd | p versus 0.50 | Cut-off | Se | 95% CI | Sp | 95% CI | + PV | 95% CI | − PV | 95% CI | + LR | 95% CI | − LR | 95% CI | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GEDV (mL/m2) | 0.59 | 0.10 | 0.47 | |||||||||||||||
| CVP (mmHg) | 0.56 | 0.11 | 0.57 | |||||||||||||||
| IVC max diameter (mm) | 0.58 | 0.11 | 0.49 | |||||||||||||||
| PPV (%) | 0.66 | 0.10 | 0.10 | |||||||||||||||
| SVV (%) | 0.61 | 0.10 | 0.10 | |||||||||||||||
| IVCDV (%) | 0.64 | 0.11 | 0.20 | |||||||||||||||
| ΔPPVPLR (% change) | − 0.77 | < 0.01 | 0.98 | 0.02 | < 0.01 | ≤ − 20% | 100 | 78–100 | 93 | 61–100 | 94 | 69–99 | 100 | 15.0 | 2.3–99.6 | 0.0 | ||
| ΔPPVPLR (abs. change) | − 0.70 | < 0.01 | 0.98 | 0.02 | < 0.01 | ≤ − 2 points | 93 | 68–100 | 93 | 68–100 | 94 | 69–99 | 94 | 69–99 | 14.0 | 2.1–93.4 | 0.1 | 0.0–0.5 |
| ΔPPVVt (% change) | 0.53 | < 0.01 | 0.94 | 0.04 | < 0.01 | > 20% | 93 | 68–100 | 87 | 59–98 | 87 | 66–96 | 94 | 69–99 | 7.0 | 1.9–25.6 | 0.1 | 0.0–0.5 |
| ΔPPVVt (abs. change) | 0.71 | < 0.01 | 0.98 | 0.02 | < 0.01 | > 1 point | 93 | 68–100 | 100 | 78–100 | 100 | 94 | 69–99 | 0.1 | 0.0–0.5 | |||
| ΔSVVPLR (% change) | − 0.66 | < 0.01 | 0.90 | 0.07 | < 0.01 | ≤ − 19% | 80 | 52–96 | 100 | 78–100 | 100 | 83 | 65–93 | 5.5 | 1.5–20.7 | 0.3 | 0.1–0.7 | |
| ΔSVVPLR (abs. change) | − 0.73 | < 0.01 | 0.88 | 0.07 | < 0.01 | ≤ − 2 points | 73 | 45–92 | 100 | 78–100 | 100 | 79 | 62–90 | 0.3 | 0.1–0.6 | |||
| ΔSVVVt (% change) | 0.07 | 0.69 | 0.82 | 0.08 | < 0.01 | > 20% | 100 | 78–100 | 67 | 38–88 | 70 | 55–81 | 75 | 60–86 | 3.0 | 1.5–6.1 | 0.0 | |
| ΔSVVVt (abs. change) | 0.21 | 0.26 | 0.94 | 0.04 | < 0.01 | > 1 point | 93 | 68–100 | 73 | 45–92 | 78 | 60–89 | 100 | 3.5 | 1.5–8.2 | 0.1 | 0.0–0.6 | |
| ΔIVCDVPLR (% change) | − 0.50 | < 0.01 | 0.76 | 0.10 | < 0.01 | ≤ − 24% | 73 | 45–92 | 87 | 85 | 83 | 59–95 | 77 | 58–89 | 5.5 | 1.5–20.7 | 0.3 | 0.1–0.7 |
| ΔIVCDVPLR (abs. change) | − 0.30 | 0.09 | 0.56 | 0.11 | 0.60 | |||||||||||||
| ΔIVCDVVt (% change) | 0.52 | < 0.01 | 0.88 | 0.06 | < 0.01 | > 4% | 100 | 78–100 | 67 | 38–88 | 75 | 60–86 | 100 | 3 | 1.5–6.1 | 0.0 | ||
| ΔIVCDVVt (abs. change) | 0.57 | < 0.01 | 0.92 | 0.05 | < 0.01 | > 1 point | 100 | 78–100 | 60 | 32–84 | 71 | 57–83 | 100 | 2.5 | 1.3–4.6 | 0.0 |
AUROC area under the receiver operating characteristic curve, CI confidence interval, GEDV global end-diastolic volume indexed for body surface, IVC inferior vena cava, IVCDV respiratory variation of the diameter of the inferior vena cava, PPV pulse pressure variation, Se sensitivity, sd standard deviation, Sp specificity, SVV stroke volume variation, + PV positive predictive value, − PV negative predictive value, + LR positive likelihood ratio, − LR negative likelihood ratio, ΔPPVPLR changes in pulse pressure variation induced by passive leg raising, ΔSVVPLR changes in stroke volume variation induced by passive leg raising, ΔIVCDVPLR changes in the respiratory variation of the diameter of the inferior vena cava induced by a tidal volume challenge, ΔPPVVt changes in pulse pressure variation induced by a tidal volume challenge, ΔSVVVt changes in stroke volume variation induced by a tidal volume challenge, ΔIVCDVVt changes in the respiratory variation of the diameter of the inferior vena cava induced by a tidal volume challenge