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. 2021 Mar 17;19:112. doi: 10.1186/s12967-021-02709-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — KPNA2 assists nucleus shuttling of CBX8. a The binding between KPNA2 and CBX8 in T24 and BIU-87 cells detected by Co-IP assay. b The PNA2 and CBX8 mRNA expression detected in T24 and BIU-87 cell lines using RT-qPCR. c The expression of KPNA2 and CBX8 in BCa cells in response to overexpressing/silencing KPNA2 determined by Western blot analysis. d The expression of CBX8 in the nucleus of BCa cells in response to overexpressing/silencing KPNA2 determined by Western blot analysis. e The expression of CBX8 in the cytoplasm of BCa cells in response to overexpressing/silencing KPNA2 determined by Western blot analysis. f The nucleus accumulation of KPNA2 and CBX8 in T24 cells by immunofluorescence staining. *p < 0.05 vs. T24 cells treated with oe-NC; ^#p < 0.05 vs. T24 cells treated with sh-NC