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. 2021 Mar 17;3:24. doi: 10.1186/s42523-021-00082-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Deletion of STM3254 leads to reduced infection numbers in C57/BL6J mice over time. Two groups of female C57/BL6J mice (n = 6 each group) were fed the PD or the WD and orally infected with a 1:1 ratio of ST4/74 and ST4/74 ΔSTM3254::Kan^R, and on group (n = 6) was fed the PD and infected with a 1:1 ration of ST4/74 ΔSTM3254::Kan^R and ST4/74 ΔSTM3254::Kan^R /pBR-3254. The total inoculum was 5 × 10⁷ CFU/mouse. Stool samples were taken every 24 h up to 3 days (a, c, e). The CFU per mg feces of each strain are shown over time. The numbers of ST4/74 (circles) ST4/74 ΔSTM3254::Kan^R (squares) (or ST4/74 ΔSTM3254::Kan^R (circles) and ST4/74 ΔSTM3254::Kan^R /pBR-3254 (squares) recovered in each mouse after co-infection are depicted. Solid horizontal lines indicate mean values while dashed lines lines represent the detection limit for each sample. b, d, f) CIs depict the ratio of ST4/74 and ST4/74 ΔSTM3254::Kan^R, or ST4/74 ΔSTM3254::Kan^R and ST4/74 ΔSTM3254::Kan^R /pBR-3254). The geometric mean for each group was compared to the theoretical value of 1.0 and the fold-change difference is indicated in parentheses. Significant differences (p value ≤0.05) are indicated by asterisks