Table 4.
Univariate and multivariate analyses of RRP in 73 patients with LS-SCLC treated with early CCRT
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Sex male | 4.74 | 0.83–89.7 | 0.0850 | 5.29 | 0.68–123 | 0.1221 |
| Age ≥ 70 years | 1.33 | 0.32–4.77 | 0.6717 | – | – | – |
| ECOG-PS = 0 | 1.22 | 0.36–4.46 | 0.7464 | – | – | – |
| V20 ≥ 25% | 2.03 | 0.61–7.42 | 0.2526 | 3.64 | 0.82–20.9 | 0.0900 |
| Pre-existing ILAs | 16.3 | 3.88–80.3 | 0.0001 | 27.7 | 3.73–105 | 0.0002 |
RRP, radiation-related pneumonitis; LS-SCLC, limited-stage small-cell lung cancer; CCRT, concurrent chemoradiotherapy; HR, hazard ratio; CI, confidence interval; ECOG-PS, Eastern Cooperative Oncology Group performance status; V20, percentage of normal lung receiving at least 20 Gy; ILA, interstitial lung abnormality;