Figure 2.
Structures of three SARS-CoV-2-neutralizing VH1-2 antibodies reveal both “RBD-down” and “RBD-up” modes of spike recognition
(A) Side and top views of three 2-43 antibody Fabs bound to the prefusion SARS-COV-2 spike in the closed state. Color schemes are 2-43, green; RBD, salmon; NTD, yellow; N-linked glycans, magenta; other spike regions, gray.
(B) Side and top views of one 2-15 antibody Fab in complex with the prefusion SARS-COV-2 spike in the closed state. 2-15 is colored blue.
(C) Overview of the crystal structure of 2-15 in complex with SARS-CoV-2 RBD. Residue segments missing in the structure are shown as dashed lines.
(D) Side and top views of one H4 Fab recognizing an up RBD on the prefusion SARS-COV-2 spike. H4 is colored cyan.