Fig. 6.

Initiation of immune memory after pseudovirus challenge in WT mice and hACE2 mouse models. (a) Representative flow cytometric analysis images of CD4⁺CD3⁺ T cells in BALF of WT mice and hACE2 mice. (b) Relative quantification of CD4⁺CD3⁺ T cells in BALF of WT mice and hACE2 mice. (c) Representative flow cytometric analysis images of CD138⁺CD45⁺ B cells in spleen of WT mice and hACE2 mice. (d) Relative quantification of CD138⁺CD45⁺ B cells in spleen of WT mice and hACE2 mice. (e) Anti-RBD IgG titer in blood of WT mice and hACE2 mice. (f) Anti-RBD sIgA titer in BALF of WT mice and hACE2 mice. (g,h) Body weight of WT (g) and hACE2 (h) mice during the one month evaluation period. (I: PBS, II: Poly(I:C), III: PL-Poly(I:C), IV: NL-Poly(I:C), V: PL-Poly(I:C)/RBD, VI: NL-Poly(I:C)/RBD).