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. 2021 Feb 24;24:140–153. doi: 10.1016/j.omtn.2021.02.019

Figure 1.

Figure 1

CD46 exon 13 skipping is upregulated in bladder cancers

(A) Schematic representation of the CD46 exons structure to highlight the alternative splicing between exons 12 and 14 generating CD46-CYT1 and CD46-CYT2 variants. (B) Diagrams for detection of CD46-CYT1 and CD46-CYT2 mRNA. Primer pairs and product sizes for the two variants are shown. (C) Expression of CD46-CYT1 and CD46-CYT2 mRNA in 27 paired bladder cancer tissues (T) and adjacent nontumor tissues (N) by RT-PCR. GAPDH transcript level was used as the loading control. The ratio for 13−/13+ is listed below the panel. (D) Quantification of data from (C) for the exon 13 exclusion inclusion ratio. The data were analyzed by a paired Student’s t test. ∗∗∗p < 0.001.