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. 2021 Feb 24;20:596–606. doi: 10.1016/j.omto.2021.02.014

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Nimbolide inhibits the expression of integrin and associated FAK signaling

(A) Focal adhesion kinase pathway-focused PCR array of cells treated with nimbolide (6 h) was performed. The differential expression of genes over 2-fold compared to control were represented in the bar diagram. The data represent mean ± SD of three replicates. (B) Immunoblotting of MDA-MB-231 cells treated with nimbolide for indicated times reveals the inhibition of integrin-FAK signaling axis. (C) Co-localization of actin and paxillin (focal adhesion point protein) was evaluated by immunofluorescence analysis (FAK, focal adhesion kinase; PAX, paxillin). (D) Immunoblot analysis of MDA-MB-231 cells treated with nimbolide at different time points shows that phosphorylated vasodilator stimulated phosphoprotein (pVASP) (both S157 and S239) and Diaphanous 1 (Diaph1) were increased (n = 3).