Table 1.
Characteristics of the included studies in animal model and treatment.
| Study | Animal model |
Treatment |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Species | Age (months) | Weight (g) | Sample size |
Target Disease | Acupoints | Moxa diameter (mm) | Duration (min) | Treatment period | ||
| Moxa (M, F) | Control (M, F) | |||||||||
| Du 26 | Wistar rat | 12 | 500 ± 20 | (10,0) | (10,0) | AD | GV20, BL23 | 6 | 15 | 14 times for 14 days |
| Liu 33 | ApoE(−/−) mice | 2 | 27 ∼ 29 | (11,0) | (11,0) | AD | CV8 | 20∼30 | 20 | 72 times for 78 days |
| Wang 27 | SD rat | 15 | 350 ∼450 | (10,0) | (10,0) | AD | GV20, BL23, ST36 | NR | 5 | 18 times for 21 days |
| Wang 28 | SD rat | 15 | 350 ∼450 | (10,0) | (10,0) | AD | GV20, BL23, ST36 | 8 | 5 | 18 times for 21 days |
| Wang 29 | SD rat | 15 | 350 ∼450 | (10,0) | (10,0) | AD | GV20, BL23, ST36 | NR | 5 | 18 times for 21 days |
| Jiang 31 | SD rat | 2 | 300 ± 30 | (11,0) | (10,0) | AD | GV20, GV4, GV1, CV4 | 10 | 3 or 7* | 10 times for 30 days |
| Wang 34 | Wistar rat | NR | 300 ± 30 | (12,0) | (12,0) | VD | GV20, GV24, GV14 | NR | 20 | 30 times for 31 days |
| Wang 37 | Wistar rat | 10 | 300 ± 30 | (12,0) | (12,0) | VD | GV20, GV24, GV14 | 2∼3 | 20 | 30 times for 31 days |
| Zhu 30 | SD rat | NR | NR | (12,0) | (12,0) | AD | GV20, GV16, GV14 | 20 | 20 | 15 times for 15 days |
| Wang 35 | SD rat | NR | 250 ± 10 | (7.0) | (7,0) | VD | GV20, GV24, GV14 | 5 | 20 | 30 times for 30 days |
| Weilan38 | Wistar rat | NR | 220 ± 20 | (7,0) | (7,0) | VD | GV20, GV16, ST36, GB20 | NR | 3 Zhuang | 24 times for 27 days |
| Luo 40 | Wistar rat | NR | 280 ± 20 | (10,0) | (10,0) | VD | CV6, CV12, CV17, SP10, TE5, ST36 | 5 | 3 or 4 Zhuang | 24 times for 27 days |
| Zhang 36 | Wistar rat | 10 | 250 ± 50 | (8,0) | (8,0) | VD | GV20, GV24, GV14 | 15 | 20 | 30 times for 31 days |
| Xiao 7 | SD rat | 2 | 350 ∼400 | (10,0) | (10,0) | AD | KI6, TE5, GB41, PC6, SP4, SI3, BL62, LU7 | NR | 9 Zhuang | 35 times for 35 days |
| Yu 32 | APP/PS1mice | 6 | NR | (12.0) | (12,0) | AD | CV4 | 20 | 15 | 48 times for 55 days |
| Zhu 39 | SD rat | NR | 200 ∼250 | (10,0) | (10,0) | VD | GV14, GV4, CV4 | NR | 15 | 24 times for 27 days |
Abbreviations: SDS, prague-Dawley; ApoE−/−, apolipoprotein E-deficient; APP/PS1, Amyloid precursor protein/presenilin-1 transgenic; M, male; F, female; AD, Alzheimer’s disease; DB, database; VD, vascular dementia; NR, not reported; NA, not applicable.
*
Jiang31 treated all participants using moxibustion for 3 min except GV20 which received moxibustion for 7 min.