Table 1.
Characteristics of subjects.
| All (n = 98) | Negative Ab (n = 22) | Single Ab Positive (n = 37) |
Multiple Positive and type 1 diabetes (n = 39) |
P Value | |
|---|---|---|---|---|---|
| Age at screening (years) | 27.2 ± 13.8 | 28.1 ± 14.6 | 31.4 ± 13.1 | 22.6 ± 13 | 0.02 |
| Sex (Female) | 56 (57%) | 9 (41%) | 26 (70%) | 21 (54%) | 0.08 |
| Race NHW Hispanic Other |
80 (82%) 16 (16%) 2 (2%) |
20 (91%) 2 (9%) 0 (0)% |
30 (81%) 7 (19%) 0 (0%) |
30 (77%) 7 (18%) 2 (5%) |
0.49 |
| BMI (kg/m2) | 25.3 ± 6.0 | 26 ± 6.1 | 26.7 ± 6.1 | 23.6 ± 5.7 | 0.10 |
| DR3 Present | 35 (36%) | 5 (24%) | 15 (41%) | 15 (38%) | 0.41 |
| DR4 Present | 53 (55%) | 6 (29%) | 21 (57%) | 26 (67%) | 0.02 |
| DR 3/4 | 13 (13%) | 1 (5%) | 5 (14%) | 7 (18%) | 0.39 |
| HbA1c % | 5.1 ± 0.4 | 5.0 ± 0.4 | 5.0 ± 0.4 | 5.3 ± 0.4 | 0.007 |
| Follow up time (years) | 7.4 ± 4.1 | 9.5 ± 3.7 | 6.2 ± 4.0 | 7.3 ± 4.0 | 0.01 |
Ab: islet autoantibody.
BMI: body mass index.
NHW: Non-Hispanic White.
P values by ANOVA, chi-square test or Fisher’s exact test were used to compare negative ab, single ab and multiple positive/type 1 diabetes cohorts.