Table 3.
Incidence of infection at 1‐year posttransplant, by intensity of desensitization (%)
| Infection | CLDKT | P‐value a | ILDKT b | P‐value c | |||
|---|---|---|---|---|---|---|---|
| None (n = 260) | Overall (n = 215) |
Low (n = 47) |
Moderate (n = 74) |
High (n = 94) |
|||
| Median number, (IQR) | 1 (0, 2) | <.001 | 1 (0, 3) | 1 (0, 3) | 1 (1, 3) | 2 (1, 4) | <.001 |
| Type | |||||||
| Urinary tract | 21.5 | .004 | 33.5 | 31.9 | 25.7 | 40.4 | .005 |
| Opportunistic | 10.8 | <.001 | 21.9 | 21.3 | 20.3 | 23.4 | .008 |
| BK virus | |||||||
| DNAemia | 18.5 | .1 | 12.6 | 14.9 | 14.9 | 9.6 | .2 |
| BKVAN | 3.1 | .005 | 9.3 | 10.6 | 9.5 | 8.5 | .02 |
| Bloodstream | 5.4 | <.001 | 19.1 | 14.9 | 14.9 | 24.5 | <.001 |
| CMV | |||||||
| DNAemia | 10.0 | .6 | 12.1 | 6.4 | 8.1 | 18.1 | .1 |
| Tissue invasive | 0.8 | .3 | 2.3 | 0.0 | 2.7 | 3.2 | .2 |
| Pneumonia | 4.6 | .002 | 12.1 | 8.5 | 10.8 | 16.0 | .005 |
| C. difficile | 3.8 | <.001 | 13.5 | 8.5 | 9.5 | 19.1 | <.001 |
| Other viral | 3.5 | .007 | 9.8 | 6.4 | 10.8 | 10.6 | .02 |
| Surgical site | 3.8 | .2 | 6.5 | 0.0 | 5.4 | 10.6 | .03 |
| Gastroenteritis | 4.6 | .8 | 5.1 | 8.5 | 1.4 | 6.4 | .2 |
| Invasive fungal | 2.3 | .02 | 7.0 | 2.1 | 2.7 | 12.8 | .001 |
| Skin/soft tissue | 2.3 | .1 | 5.1 | 2.1 | 4.1 | 7.4 | .1 |
Abbreviations: BKVAN, BK virus‐associated nephropathy; C. difficile, C lostridium difficile; CMV, cytomegalovirus; IQR, interquartile range.
a
p‐value tests difference between overall ILDKT vs. CLDKT.
b
Low (0‐4 plasmaphereses), moderate (5‐9 plasmaphereses), and high (≥10 plasmaphereses).
c
p‐value tests difference between intensity of desensitization vs. CLDKT.