Table 1.

Literature review in case reports preenting a therapy in a pregnant female with severe hypertriglyceridemia (HTG).

Author and year	Admission time to hospital	Intervention	Results	Conclusions
Kleess el al., 2018 (11)	21st weeks of pregnancy	Insulin along with low-fat (<20% of calories) and low-carbohydrate diet	TG reduced from 7,812 to 1,800 mg/dL	A multidisciplinary team, along with a dietitian, can effectively improve severe HTG.
Safi et al., 2014 (16)	28th weeks of pregnancy	Plasmapheresis and intravenous heparin	TG reduced from 2,661 to 608 mg/dL after 5 days	Plasmapheresis for rapid reduction of TG and heparin for keep TG low
Gupta et al., 2014 (17)	38th weeks of pregnancy	Plasmapheresis and fibrate derivatives as well as low fat, restricted calorie clear liquid diet.	TG reduced from 12570 to 295 mg/dL after 8 days	Plasmapheresis is an intensive treatment to reduce TG in patients with HTG dramatically
Basar et al., 2013 (18)	21st weeks of pregnancy	Medical nutrition therapy, ω-3 fatty acids 3 g/day, and NPH insulin were started and continued with plasmapheresis	TG reduced from 12,000 mg/dL to 1,121 mg/dL after 12 days	Plasmapheresis was more effective than medical nutrition therapy and insulin infusion
Vandenbroucke et al., 2008 (15)	37th weeks of pregnancy	A course of heparin and a low-fat diet	TG reduced from 84,470 to 240 mg/dL after 6 days	Heparin and a low-fat diet can quickly decrease triglyceridemia and the healing of acute pancreatitis.
Gürsoy et al., 2005 (13)	37th weeks of pregnancy	Continuous intravenous insulin–glucose	TG reduced from 10,092 to 608 mg/dL after 5 days	Intravenous insulin and cessation of oral intake leads to dramatically decreased the triglyceride levels
Sleth et al., 2004 (14)	37th weeks of pregnancy	A single dose of heparin per day and a very low-fat diet	TG reduced from 950 to 100 mg/dL after 48 h	Heparin along with intravenous nutrition is immediate action in the management of severe HTG
Shenhav et al., 2002 (10)	33rd weeks of pregnancy	Intravenous hydration with 3,000 mL of 5% dextrose and a hypocaloric low-carbohydrate, low-fat diet containing 10 g fat per day and MCT	TG reduced from 13,805 to 1,035 mg/dL after 27 days	Dietary intervention was helpful; however, its effect not acute.
Sanderson et al., 1991 (12)	33rd weeks of pregnancy	Intravenous fluids with the reinstitution of a low-fat diet.	TG reduced from 6,637 to 265 mg/dL after 7 days	Parenteral nutrition with a low-fat content was enough to improve HTG