Table 1.
Micro RNAs targets and functions in cardiomyocyte apoptosis.
| Functions | miRNA | Up/down | Targets | Reference | |
|---|---|---|---|---|---|
| Cardiomyocyte apoptosis | Pro-apoptosis | 195 | Up | SIRT1 | PMID:21622680 |
| 195 | Up | Bcl2 | PMID:27489501 | ||
| 22 | Up | SIRT1 | PMID:27174562 | ||
| 15 | Up | Bcl2 | PMID:28814571 | ||
| 155 | Up | Capase3 | PMID:31191799 | ||
| 665 | Up | AKT/Cnr2 | PMID:31026731 | ||
| 206 | Down | ATG3 | PMID:29880830 | ||
| 206 | Down | ATG3 | PMID:30551524 | ||
| 17 | Down | Apaf-1 | PMID:26265044 | ||
| 762 | Down | ND2 | PMID:31235686 | ||
| 340 | Down | Act1 | PMID:30989715 | ||
| 124 | Down | CircHipk3 | PMID:31799682 | ||
| 498 | Down | PAWR | PMID:32767028 | ||
| Anti-apoptosis | 133 | Up | SIRT3 | PMID:32575874 | |
| 378 | Up | Capase3 | PMID:22119805 | ||
| 488 | Up | Capase3 | PMID:31210328 | ||
| 206 | Up | FoXP1 | PMID:26333362 | ||
| 21 | Up | PDCD4 | PMID:29674977 | ||
| 325 | Up | RIPK3 | PMID:31248365 | ||
| 24 | Up | – | PMID:25352422 | ||
| 210 | Up | AIFM3 | PMID:32513270 | ||
| 410-3p | Up | TRAF5 | PMID:31696495 | ||
| 182 | Up | Nogo-C | PMID:27763637 | ||
| 24-3p | Up | Nrf2 | PMID:30622671 | ||
| 486 | Up | PI3k/AKT | PMID:30844685 | ||
| 7a-5p | Up | BTG2 | PMID:32945347 | ||
| 323-3p | Up | TGF-β2 | PMID:32633390 | ||
| 125-b | Up | p53/BAK1 | PMID:30613290 | ||
| 146a | Up | EGR | PMID:30362610 | ||
| let-7d | Up | HMGA | PMID:30934671 | ||
| 23a/92a | Down | – | PMID:28662151 | ||
| 145 | Down | Dusp6 | PMID:30883744 | ||
| 489 | Down | IGF1 | PMID:32880387 | ||
| 7a-5p | Down | – | PMID:33029099 | ||
| 363 | Down | Notch | PMID:28402919 | ||
| 429 | Down | Notch | PMID:27082497 | ||
| 200-c | Down | GATA-4 | PMID:28440427 | ||
| 327 | Down | ARC | PMID:31587299 |
miRNAs are divided into pro-apoptosis and anti-apoptosis according to functions. The pro-apoptosis of main targets include SIRT, Bcl, caspase, and ATG3 and the anti-apoptosis of main targets include SIRT, caspase, and AKT.