Table 3.
Micro RNAs targets and functions in cardiomyocyte hypertrophy.
| Functions | miRNA | Up/down | Targets | Reference | |
|---|---|---|---|---|---|
| Cardiomyocyte hypertrophy | Pro-hypertrophy | 208 | Up | Trβ1/MYH7 | PMID:19726871 |
| 27 | Up | Trβ1/MYH7 | PMID:21149577 | ||
| 27 | Up | PDLIM5 | PMID:32370947 | ||
| 212/132 | Up | Ang II | PMID:23011132 | ||
| 22 | Up | SIRT | PMID:23524588 | ||
| 22 | Up | PTEN | PMID:21618527 | ||
| 206 | Up | FoXP1 | PMID:26333362 | ||
| 340 | Up | DMD1 | PMID:26084457 | ||
| 365 | Up | SKP2 | PMID:28130111 | ||
| 195 | Up | MFN2 | PMID:31341888 | ||
| 20 | Up | MFN2 | PMID:31295012 | ||
| 10 | Down | TNX5 | PMID:28100873 | ||
| 200 | Down | MLCK | PMID:30680929 | ||
| 34 | Down | Ang II | PMID:24728149 | ||
| 1 | Down | CDK6/NFAT | PMID:26699910 | ||
| 133a | Down | RhoA | PMID:17468766 | ||
| Anti-hypertrophy | 1 | Up | FbIn2 | PMID:23612897 | |
| 541 | Up | MITF | PMID:24722296 | ||
| let-7 | Up | CaM | PMID:28123343 | ||
| 142 | Up | SH2B1 | PMID:30372837 | ||
| 672 | Up | JUN | PMID:29339068 | ||
| 144 | Up | MOTR | PMID:30084039 | ||
| 181 | Down | – | PMID:32538237 | ||
| 410/495 | Down | – | PMID:26999812 | ||
| 495 | Down | PTEN | PMID:29566365 |
miRNAs are divided into pro-hypertrophy and anti-hypertrophy according to functions. The pro-hypertrophy of main targets include Trβ1/MYH7, MFN2, and Ang II and the anti-hypertrophy of main targets include MOTR, PTEN, and CaM.