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. 2021 Mar 5;12:640916. doi: 10.3389/fimmu.2021.640916

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Copyright © 2021 Morrison and McShane.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Samples that can be obtained from the human pulmonary compartment from immunological interrogation. (B) Selected components of the pulmonary mucosal immune system that may be involved in protection against Mycobacterium tuberculosis (M.tb). AM, alveolar macrophages; CD, cluster of differentiation; CXCR, C-X-C chemokine receptor; FBC, follicular dendritic cell; GM-CSF, granulocyte-macrophage colony-stimulating factor; iBALT, inducible bronchus-associated lymphoid tissue; IFN, interferon; ILC, innate lymphoid cells; IM, interstitial macrophages; IL, interleukin; KLRG, killer-cell lectin like receptor G; MAIT, mucosal-associated invariant T-cells; PD, programmed cell death protein; sIgA, secretory immunoglobulin A; TCR, T-cell receptor; TNF, tumor necrosis factor; TRM, tissue-resident memory T-cell. Created with BioRender.com.