Table 1.

Multiplex analysis of plasma.

No	Analytea	Day 0 median	Day 0 (IQR)	6M median	6M (IQR)	p-valueb
T cell response related
1	IFN-gamma	53	34.1–80.3	27	19.8–37.7	<0.0001
2	IL-18	116	30.5–187.6	51	18.5–104.3	<0.0001
3	CD40-Ligand	236	0–305	0	0–245	<0.0001
4	IP-10	240	109–375	67	24–148	<0.0001
5	MIG	968	707–1256	526	0–715.5	<0.0001
6	IL-16	1,637	1,107–1,840	1,119	743–1,610	<0.0001
7	IL-2R	25,084	15,178–40,542	7,953	4,746–13,525	<0.0001
8	TSLP	19	9.9–30.5	4	0–15	0.0006
9	I-TAC	314	0–735	0	0–326	0.0014
10	IL-2	32	11.5–91.1	18	11.5–106.7	0.19
11	IL-21	98	0–222.3	62	0–200.4	0.1
12	IL-17A	348	56–690	309	135.7–674.5	0.26
TNF superfamily related
13	TNF-RII	662	585–717	569	521–633	<0.0001
14	Tweak/TNFSF12	2,266	1,286–3,432	1,306	909–1,779	<0.0001
15	CD30	10,436	7,935–14,690	4,673	3,001–6,851	<0.0001
16	ENA-78(LIX)	859	407–1,973	603	323–1,425	0.004
17	APRIL	4,274	3,390–5,268	3,836	2,893–4,846	0.005
18	TNF-alpha	3	1.48–7.6	3	0.35–4.06	0.027
19	TRAIL	682	0–966	0	0–804	0.034
20	BAFF	49	0–96.7	0	0–126.6	0.427
Monocyte/macrophage related
21	MCP-2	25	12.9–38.9	11	6.6–15.7	<0.0001
22	MIP-1alpha	17	13–24	10	6.1–15	<0.0001
23	BLC	1,113	593.5–2,170	422	155.7–755.8	<0.0001
24	Eotaxin-3	72	0–102.8	0	0–36.7	0.0002
25	MDC/CCL22	4,374	1,529–10,229	1,515	446–4,264	0.0004
26	MIP-3alpha	26	9.7–55.9	10	2.7–35.1	0.0016
27	MIP-1beta	61	30.2–92.2	42	14.1–63.4	0.008
28	Eotaxin-2	6	0.9–20.3	2	0–12.3	0.071
29	Fractalkine	16	9.5–29.9	12	5.5–23	0.074
30	MCP-1	253	121.7–388.2	211	104.6–319.7	0.22
31	Eotaxin-1	14	7.3–38.7	11	5.6–47.9	0.78
Growth factors
32	VEGF-A	815	512.7–1,055	425	223.2–658.8	<0.0001
33	HGF	565	427.7–714	456	329–502.6	0.0005
34	MMP-1	1,879	1,065–4,429	1,649	764–2,731	0.049
35	SDF-1alpha	7,690	6,142–8,754	6,940	5,496–8,884	0.085
36	SCF	38	23.1–48.8	34	17.4–48.8	0.59

^aanalyte concentrations expressed as median (IQR) pg/ml;

^bWilcoxon matched pairs (n = 39).