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. 2021 Mar 5;9:639704. doi: 10.3389/fcell.2021.639704

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Copyright © 2021 Khan, Jiang, Hameed and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed model of free fatty acid (FFA) mobilization and catabolism in COC. (A) Free fatty acids or non-esterified fatty acids (NEFAs) are incorporated with serum albumin and are transported to follicular fluids by fatty acid carrier or directly diffused through lipid bilayer. (B) The mobilization of triacylglycerol from lipoproteins in follicular fluids occurs due to enzymatic action of lipoprotein lipases through which free fatty acids are generated and become available for cellular uptake. (C) Intracellular triacylglycerols are stored in the cumulus cells and oocytes in the form of lipid droplets. These lipid droplets are activated and further liberate free fatty acids by lipase mediated hydrolysis. (D) All the liberated free fatty acids either intracellularly from lipid droplets or through transporter molecules from follicular fluids, are metabolized in the mitochondria and ATP is generated through β-oxidation.