Table 4.
Demographic and radiomic features significantly associated with survival duration for each mutation-positive group as determined by multivariate Cox regression analysis.
| Group | Features | coef | se(coef) | z | p | Lower 0.95 | Upper 0.95 | |
|---|---|---|---|---|---|---|---|---|
| EGFR | Age | 2.76 | 0.42 | 6.56 | <0.001 | 1.93 | 3.58 | |
| Race Caucasian | 0.96 | 0.14 | 6.83 | <0.001 | 0.69 | 1.24 | ||
| Sex Male | 0.89 | 0.14 | 6.34 | <0.001 | 0.62 | 1.17 | ||
| Edema/Tumor Ratio | −3.71 | 0.99 | −3.74 | <0.001 | −5.65 | −1.76 | ||
| Tumor Number | 1.78 | 0.38 | 4.75 | <0.001 | 1.05 | 2.52 | ||
| Edema Median Intensity* | 1.37 | 0.43 | 3.21 | 0.001 | 0.54 | 2.21 | ||
| Tumor Texture** | −1.41 | 0.59 | −2.40 | 0.016 | −2.56 | −0.26 | ||
| ALK | Tumor Number | 3.05 | 0.60 | 5.12 | <0.001 | 1.88 | 4.21 | |
| Edema Median Intensity* | −1.76 | 0.88 | −2.00 | 0.045 | −3.48 | −0.04 | ||
| KRAS | Edema/Tumor Ratio | −16.80 | 3.89 | −4.33 | <0.001 | −24.50 | −9.22 | |
| Tumor Number | −1.06 | 0.45 | −2.32 | 0.020 | −1.95 | −0.17 |
Coef, Cox regression coefficient; se(coef), standard error of the Cox regression coefficient; lower 0.95, the lower bound of the 95% confidence interval; upper 0.95, the upper bound of the 95% confidence interval;
*
Edema Median Intensity, Edema_Intensity_squareroot_Intensity_Median;
**
Tumor Texture, Tumor Texture log_sigma_3-mm_3D GLRLM LongRunHighGrayLevelEmphasis; EGFR, epidermal growth factor receptor; ALK, anaplastic lymphoma kinase; KRAS, Kirsten rat sarcoma viral oncogene homolog.