Table 4.

Demographic and radiomic features significantly associated with survival duration for each mutation-positive group as determined by multivariate Cox regression analysis.

Group	Features	coef		se(coef)	z	p	Lower 0.95	Upper 0.95
EGFR	Age	2.76		0.42	6.56	<0.001	1.93	3.58
	Race Caucasian	0.96		0.14	6.83	<0.001	0.69	1.24
	Sex Male	0.89		0.14	6.34	<0.001	0.62	1.17
	Edema/Tumor Ratio	−3.71		0.99	−3.74	<0.001	−5.65	−1.76
	Tumor Number	1.78		0.38	4.75	<0.001	1.05	2.52
	Edema Median Intensity*	1.37		0.43	3.21	0.001	0.54	2.21
	Tumor Texture**	−1.41		0.59	−2.40	0.016	−2.56	−0.26
ALK	Tumor Number	3.05		0.60	5.12	<0.001	1.88	4.21
	Edema Median Intensity*	−1.76		0.88	−2.00	0.045	−3.48	−0.04
KRAS	Edema/Tumor Ratio	−16.80		3.89	−4.33	<0.001	−24.50	−9.22
	Tumor Number	−1.06		0.45	−2.32	0.020	−1.95	−0.17

Coef, Cox regression coefficient; se(coef), standard error of the Cox regression coefficient; lower 0.95, the lower bound of the 95% confidence interval; upper 0.95, the upper bound of the 95% confidence interval;

^*Edema Median Intensity, Edema_Intensity_squareroot_Intensity_Median;

^**Tumor Texture, Tumor Texture log_sigma_3-mm_3D GLRLM LongRunHighGrayLevelEmphasis; EGFR, epidermal growth factor receptor; ALK, anaplastic lymphoma kinase; KRAS, Kirsten rat sarcoma viral oncogene homolog.