Table 3.
Sensitivity, specificity, positive predictive values (PPV), negative predictive values (NPV), missed Crohn's disease (CD) diagnosis, and number of endoscopies not required when various fecal calprotectin thresholds were used in diagnosing CD.
| Fecal calprotectin threshold | n | Sensitivity, % (95% CI) | Specificity, % (95% CI) | PPV, % (95% CI) | NPV, % (95% CI) | Missed IBD, n (%) | Endoscopy not required, n (%) |
|---|---|---|---|---|---|---|---|
| >50 μg/g | 93 | 95.9 (86.3–99.3) | 52.3 (37.9–66.3) | 69.1 (57.4–78.8) | 92.0 (75.0–98.6) | 2 (2) | 25 (27) |
| >100 μg/g | 93 | 91.8 (80.8–98.8) | 59.1 (44.4–72.3) | 71.4 (59.3–81.1) | 86.7 (80.3–94.7) | 4 (4) | 30 (32) |
| >150 μg/g | 93 | 89.8 (78.2–95.6) | 63.6 (48.9–76.2) | 73.3 (61.0–72.9) | 84.8 (69.1–93.4) | 5 (5) | 33 (35) |
| >200 μg/g | 93 | 85.7 (73.3–92.9) | 65.9 (51.1–78.1) | 73.7|| (61.1–83.4) | 80.6 (65.0–90.3) | 7 (8) | 36 (39) |
| >250 μg/g | 93 | 83.7 (71.0–91.5) | 65.9 (51.1–78.1) | 73.2 (60.4–83.0) | 78.4 (62.8–88.6) | 8 (9) | 37 (40) |
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Odds ratio was 11.6 (95% CI 4.1–28.8), p < 0.0001 likelihood of having IBD.
CI, confident interval; n, sample size.