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. 2021 Mar 5;12:615104. doi: 10.3389/fphar.2021.615104

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Copyright © 2021 Wang, Wei, Chang, Dong, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Technology road map of MRI-guided focused ultrasound-induced blood–brain barrier disruption to deliver BDNF retrovirus into the brain. BDNF retrovirus is released to the target cell in the brain after the microbubbles destroying and inducing blood–brain barrier disruption by MRI-guided focused ultrasound at the site of the target brain tissue.