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. 2021 Mar 5;12:615104. doi: 10.3389/fphar.2021.615104

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Copyright © 2021 Wang, Wei, Chang, Dong, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Morris water maze test results. (A) Schematics show the treatments. AD rat models were testing two weeks after injecting with Aβ (1–40). Then, every group was treated for 4 times (2 times per one week). A month after treatment, the cognitive behaviors were detected again. (B) The representative swimming tracks during the memory test carried out on day 8 by removing the hidden platform. (C) The average escape latency to find the platform tested on day 8. (D) Target quadrant activity time tested on day 8. (E) Target platform traversing times tested on day 8. *p < 0.05, compared with U + MpLXSN-BDNF group before treatment. #p < 0.05, compared with the control group. ##p < 0.01, compared with the control group.