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. 2021 Mar 1;24:212–222. doi: 10.1016/j.omtn.2021.02.028

Figure 3.

Figure 3

Prospective transmission pathway of circRNAs in SLE

circRNAs generated in blood cells may enter serum via exosomes or cell breakage. These circRNAs then enter other blood cells or transmit to tissue fluid and enter tissue cells, causing immune response, inflammation, and cell damage. Accordingly, circRNAs generated in tissue cells may also influence other tissue cells and blood cells.