Table 1.
circRNAs in some autoimmune diseases
| circRNAs | Diseases | Samples | Expression | Roles | References |
|---|---|---|---|---|---|
| Hsa_circ_0088036 | RA | PBMCs | up | promotes the proliferation and migration of fibroblast-like synoviocytes | Zhong et al.53 |
| Hsa_circ_0002715 | RA | peripheral blood | up | correlated with SJC, TJC, disease duration, RF, ACPA, and hematologic disorder; diagnostic markers | Luo et al.54 |
| Hsa_circ_0035197 | RA | peripheral blood | up | correlated with hematologic disorder | Luo et al.54 |
| Hsa_circ_0000367 | RA | peripheral blood | up | diagnostic marker | Luo et al.54 |
| Hsa_circ_0001947 | RA | peripheral blood | up | – | Luo et al.54 |
| Hsa_circ_0000396, hsa_circ_0130438 | RA | PMBCs | down | diagnostic marker | Yang et al.55 |
| CiRS-7 | RA | PMBCs | up | diagnostic marker; regulates miR-7/mTOR axis | Tang et al.56 |
| Hsa_circ_0044235 | RA | peripheral blood | down | diagnostic marker | Luo et al.57 |
| Circ_0005402 and Circ_0035560 | MS | leukocytes | down | biomarker | Iparraguirre et al.58 |
| Hsa_circRNA_101062, hsa_circRNA_100332, hsa_circRNA_085129, hsa_circRNA_103845 | T1DM | plasma | up | – | Li et al.59 |
| Circ-IQGAP2, circ-ZC3H6 | SS | minor salivary gland; plasma exosomes | up | correlated with clinical features, serum IgG level, and MSG focus scores; diagnostic markers | Li et al.60 |
| Hsa_circRNA_001264, hsa_circRNA_104121, hsa_circRNA_045355 | SS | PBMCs | up | correlated with clinical, laboratory parameters, and disease activity index; diagnostic markers | Su et al.61 |
PBMCs, peripheral blood mononuclear cells; SJC, swollen joint count; TJC, tender joint count; RF, rheumatoid factor; ACPA, anticitrullinated protein antibodies; MS, multiple sclerosis; T1DM, type 1 diabetes mellitus; SS, Sjögren’s syndrome; IgG, immunoglobulin G; MSG, minor salivary gland.