Table 2.

circRNAs in SLE

circRNAs	Samples	Expression	Roles	References
Hsa_circ_0044235	PBMCs	down	diagnostic marker; associated with anti-dsDNA and anti-ribosomal P antibodies	Luo et al.70
Hsa_circ_0068367	PBMCs	down	diagnostic marker	Luo et al.70
CircPTPN22	PBMCs	down	diagnostic marker and disease severity indicator	Miao et al.71
Hsa_circ_0021372, hsa_circ_0075699	peripheral blood	down	associated with C3 and C4 levels	Li et al.72
Hsa_circ_0057762	peripheral blood	up	positively associated with the SLEDAI-2K score; diagnostic marker	Li et al.72
Hsa_circ_0003090	peripheral blood	up	diagnostic marker	Li et al.72
Hsa_circRNA_407176, hsa_circRNA_001308	plasma, PBMCs	down	diagnostic marker	Zhang et al.73
Hsa_circRNA_406567	PBMCs	down	diagnostic marker	Zhang et al.73
circRNA_002453	Plasma	up	associated with the severity of renal involvement; diagnostic marker	Ouyang et al.74
Hsa_circ_0049224, has_circ_0049220	PBMCs	down	associated with DNMT1 expression, disease activity and clinical characteristics	Zhang et al.75
Hsa_circ_0000479,	PBMCs	up	associated with clinical characteristics and therapeutic effect; diagnostic marker	Guo et al.,76 Luo et al.77
Hsa_circ_0082689, hsa_circ_0082689	PBMCs	up	associated with clinical characteristics and therapeutic effect	Luo et al.77
Hsa_circ_0045272	T cells	down	binding with hsa-miR-6127; negatively regulating apoptosis and interleukin-2 secretion of Jurkat cells	Li et al.78
CircIBTK	PBMCs	down	disease marker; regulate DNA demethylation and AKT signaling pathway via binding to miR-29b	Wang et al.79
Hsa_circ_0012919	CD4+ T cells	up	associated with SLE characters; increase DNMT1 expression; regulate DNA hypomethylation and expression of CD70 and CD11a; regulate KLF13, RANTES and MDA5 by miR-125a-3p	Zhang et al.80,81
dsRNA-containing circRNA	PBMCs	down	alleviate the aberrant PKR activation cascade	Kato et al.82

dsDNA, double-stranded DNA; SLEDAI, Lupus Erythematosus Disease Activity Index.