Figure 13.

C-termini of ENaC subunits have overlapping PPPxY- and YxxΦ-motifs.A, schematic representation of α, β, and γENaC illustrating the extracellular loop, two transmembrane domains (black rectangles), and intracellular N- and C-termini. The position within the C-terminus of each subunit at which a truncation mutation was introduced and the localization of the highly conserved PPPxYxxL sequence are indicated by asterisks. B, primary sequence alignment of the corresponding C-terminal regions of human αβγENaC. Highly conserved amino acid residues belonging to PPPxY- and YxxΦ-motifs are highlighted in bold.