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. 2021 Feb 10;296:100404. doi: 10.1016/j.jbc.2021.100404

Figure 16.

Figure 16

YxxΦ-motif of β- and γENaC is critically involved in Cx30-mediated ENaC inhibition.A, ΔIAmi values obtained in oocytes expressing wild-type (αβγ), truncated (αβγK626X, αβγA635X), or mutant (αβγL630D, αβL623Dγ, αβL623DγL630D) ENaC with or without Cx30 were normalized as described in Figure 12A. Mean ± SEM and data points for individual oocytes are shown; ∗∗∗p < 0.001; ∗∗p < 0.01; n.s., not significant; Kruskall–Wallis with Dunn’s post hoc test (30 ≤ n ≤ 172, 3 ≤ N ≤ 4). B, relative inhibitory effect of Cx30 on wild-type (αβγ), truncated (αβγK626X, αβγA635X), or mutant (αβγL630D, αβL623Dγ, αβL623DγL630D) ENaC calculated as described in Figure 12B using original data shown in (A). Mean ± SEM and data points for individual oocytes are shown; ∗∗∗p < 0.001; n.s., not significant; Kruskall–Wallis with Dunn’s post hoc test.