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. 2021 Mar 5;12:631891. doi: 10.3389/fphar.2021.631891

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Copyright © 2021 Gan, Cheng, Ke, Sun, Jia, Chen, Lin, Li, Xu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PFD attenuated symptoms and synovitis in CIA rats and reduced the expression of VEGF in the knee joints (A) Flow chart of the experimental design. (B) Representative images of the hind paws of CIA rats (C) B ultrasonic images of the knee joint in the anteroposterior position. (D) H&E staining was used to analyze pathological changes of the knee joints (E) Immunohistochemical staining results for VEGF. (F-H) Semiquantitative data are shown as means ± SD of six rats per group. *p < 0.05. In vivo experimental data are indicated by gray coloring in the figures.