Table 2.

Univariate analysis for prognostic association of target genes and other covariates in B-ALL patients.

Variables	Relapse free survival			Event free survival			Overall survival
	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value
Age at diagnosis
<10 years	Ref			Ref			Ref
≥10 years	2.22	1.080–4.599	0.029	2.481	1.412–4.360	0.002	3.038	1.405–6.565	0.005
Sex
Male	Ref			Ref			Ref
Female	1.361	0.640–2.896	0.424	1.158	0.644–2.083	0.622	0.898	0.407–1.980	0.790
WBC count (X109/L)
<50	Ref			Ref			Ref
≥50	1.060	0.477–2.386	0.874	1.378	0.760–2.499	0.290	2.034	0.934–4.432	0.074
Cytogenetics
ETV6-RUNX1/Hyperdiploidy	Ref			Ref			Ref
BCR-ABL/E2A-PBX1/Hypodiploidy	3.144	1.026–9.636	0.045	2.219	0.917–5.365	0.077	2.051	0.550–7.647	0.284
B-others	0.841	0.308–2.292	0.736	0.825	0.390–1.746	0.617	1.141	0.383–3.400	0.812
Minimal residual disease (MRD)
Negative	Ref			Ref			Ref
Positive	2.67	1.474–4.836	0.001	2.162	1.346–3.473	0.001	1.461	0.700–3.046	0.312
Cerebrospinal fluid
Negative	Ref			Ref			Ref
Positive	1.713	0.232–12.629	0.597	3.619	1.296–10.099	0.014	5.200	1.550–17.44	0.008
NCI risk
Standard risk	Ref			Ref			Ref
High risk	1.139	0.561–2.312	0.718	1.458	0.823–2.582	0.196	1.933	0.840–4.449	0.121
Prednisolone response
Sensitive	Ref			Ref		Ref
Resistant	0.630	0.191–2.077	0.448	1.157	0.562–2.382	0.692	1.894	0.794–4.513	0.149
EMP1 expression
Low	Ref			Ref			Ref
High	2.603	1.163–5.823	0.020	1.794	0.998–3.225	0.050	1.698	0.756–3.813	0.199
CASP1 expression
Low	Ref			Ref			Ref
High	1.684	0.816–3.475	0.158	0.612	0.337–1.111	0.107	0.344	0.159–0.747	0.007
NLRP3 expression
Low	Ref			Ref			Ref
High	0.682	0.279–1.664	0.401	0.530	0.297–0.945	0.032	0.287	0.124–0.663	0.003

Bold values highlights significant associations.