Table 3.

Multivariate Cox regression analysis for prognostic association of EMP1 in B-ALL patients.

Variables	Relapse free survival			Event free survival			Overall survival
	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value
Age at diagnosis
<10 years	Ref			Ref			Ref
≥10 years	3.415	1.363–8.554	0.009	3.592	1.739–7.420	0.001	3.074	1.158–8.159	0.024
Sex
Male	Ref			Ref			Ref
Female	2.244	0.907–5.550	0.080	1.157	0.592–2.259	0.669	0.651	0.270–1.570	0.340
WBC count (X109/L)
<50	Ref			Ref			Ref
≥50	1.520	0.563–4.105	0.408	1.920	0.928–3.970	0.078	2.274	0.859–6.015	0.098
Cytogenetics
ETV6-RUNX1/Hyperdiploidy	Ref			Ref			Ref
BCR-ABL/E2A-PBX1/Hypodiploidy	6.242	1.611–24.176	0.008	3.076	1.097–8.620	0.033	2.017	0.474–8.579	0.342
B-others	1.119	0.363–3.449	0.844	0.870	0.374–2.020	0.746	0.888	0.268–2.942	0.846
Minimal residual disease (MRD)
Negative	Ref			Ref			Ref
Positive	3.142	1.581–6.241	0.001	2.186	1.308–3.654	0.003	1.386	0.649-2.960	0.398
Cerebrospinal fluid
Negative	Ref			Ref			Ref
Positive	0.952	0.100–9.001	0.966	3.407	1.087–10.681	0.035	5.859	1.540–22.285	0.009
NCI risk
Standard risk	Ref			Ref			Ref
High risk	0.430	0.150–1.230	0.116	0.623	0.282–1.375	0.242	0.777	0.246–2.447	0.667
Prednisolone response
Sensitive	Ref			Ref			Ref
Resistant	0.539	0.151–1.921	0.341	1.390	0.639–3.025	0.405	1.895	0.719–4.995	0.196
EMP1 expression
Low	Ref			Ref			Ref
High	2.114	0.916–4.880	0.079	1.214	0.622–2.368	0.569	1.035	0.411–2.609	0.940

Bold values highlights significant associations.